HLA mismatching in transplantation
نویسندگان
چکیده
منابع مشابه
Towards selective HLA mismatching in clinical transplantation.
In this issue, Kosmoliaptsis et al. (1) describe a new algorithm to determine the immunogenicity of a mismatched human leukocyte antigen (HLA) alloantigen with respect to the humoral immune response. Both in organ and hematopoietic stem-cell transplantation, the best transplant results are obtained with fully HLA-matched donor recipient combinations. However, because of the enormous polymorphis...
متن کاملLimits of HLA mismatching in unrelated hematopoietic cell transplantation.
HLA matching between the donor and recipient improves the success of unrelated hematopoietic cell transplantation (HCT). Matched donors are available for only a minority of patients. Further information is needed to evaluate the limits of HLA mismatching. We examined the association of mortality with HLA-A, -B, -C, -DRB1, and -DQB1 mismatching in 948 patients who received a T-replete unrelated ...
متن کاملHLA Mismatching Strategies for Solid Organ Transplantation – A Balancing Act
HLA matching provides numerous benefits in organ transplantation including better graft function, fewer rejection episodes, longer graft survival, and the possibility of reduced immunosuppression. Mismatches are attended by more frequent rejection episodes that require increased immunosuppression that, in turn, can increase the risk of infection and malignancy. HLA mismatches also incur the ris...
متن کاملAcceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia.
We retrospectively analyzed the effect of HLA mismatching (HLA-A, -B, -C, -DRB1, -DQB1) with molecular typing on transplantation outcome for 301 patients with acquired severe aplastic anemia (SAA) who received an unrelated BM transplant through the Japan Marrow Donor Program. Additional effect of HLA-DPB1 mismatching was analyzed for 10 of 10 or 9 of 10 HLA allele-matched pairs (n = 169). Of th...
متن کاملClinical implications of HLA locus mismatching in unrelated donor hematopoietic cell transplantation: a meta-analysis
It remains controversial that the impacts of individual HLA locus mismatches on clinical outcomes of patients receiving unrelated-donor hematopoietic cell transplantation (HCT), as compared to HLA allele matched controls. We conducted a meta-analysis to address these issues. Four databases (PubMed, Embase, Web of Science and the Cochrane Library) were searched to select eligible studies. All do...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2014-12-619015